Business
LinkedIn’s Reid Hoffman Launches Manas AI, a New Bio Startup

LinkedIn co-founder Reid Hoffman became a billionaire when Microsoft bought LinkedIn in 2016 for $26.2 billion in cash, and he has also made his fortune on high-return investments in more than 80 tech startups, including Airbnb, Groupon, and Flickr. He famously made $111 million from his initial $37,500 investment in Facebook.
Now Hoffman is turning his attention to AI in healthcare with a new startup he introduced last week with co-founder Dr. Siddhartha Mukherjee: Manas AI. And this time Hoffman has deeper hopes than just a high return on investment — he wants to help cure cancer.
Manas is bringing AI to some of the world’s top drug development scientists to deepen their expertise and speed up the rate at which new drugs are discovered. The startup aims to unite researchers with advanced AI systems to more quickly figure out how potentially life-saving drugs could interact with the human body.
Related: LinkedIn’s Reid Hoffman: To Scale, Do Things That Don’t Scale
Manas is initially turning its attention to aggressive cancers like breast cancer, prostate cancer, and lymphoma. Its long-term vision is to fundamentally change how the industry discovers and develops new medicines.
“Most people have had friends, family members, etc., who’ve died from cancer or had serious cancer problems,” Hoffman told CNBC on Monday. “If we can make a huge difference on this, and this is the kind of thing that AI can make a huge difference in, it’s the kind of reason why AI can be great for humanity.”
Reid Hoffman The Midway SF on December 05, 2023, in San Francisco, California. Photo by Kimberly White/Getty Images for WIRED
The startup has raised $24.6 million in seed funding so far, with Hoffman leading the funding round with venture capital firm General Catalyst. It will operate its AI systems in data centers owned by Microsoft.
Related: Reid Hoffman: To Successfully Grow A Business, You Must ‘Expect Chaos’
Mukherjee is a Columbia University professor and author of “The Emperor of All Maladies,” a book about cancer. In 2016, he helped found Vor BioPharma, a cell engineering company, and in 2021 he founded Myeloid Therapeutics, a cancer therapy startup.
Manas currently has four employees including Mukherjee and Hoffman, with Hoffman saying he serves as the company’s “AI guy” and Mukherjee as the “bio guy.” Manas’ goal is to unite the two fields.
“It isn’t just the best of science and it isn’t just the best of AI, because either of those two [is] insufficient,” Hoffman told CNBC. “You need to put those two together.”
The AI healthcare sector saw substantial investments in 2024. According to PitchBook, investors poured $10.5 billion into 511 healthcare AI deals in 2024. Cancer screening AI startup Freenome raised the most money out of the group with a $254 million Series F in February 2024.

A blog which focuses on business, Networth, Technology, Entrepreneurship, Self Improvement, Celebrities, Top Lists, Travelling, Health, and lifestyle. A source that provides you with each and every top piece of information about the world. We cover various different topics.
Business
17 Surprising Ways 7-Figure Solopreneurs Are Using AI — And You’re Not

Opinions expressed by Entrepreneur contributors are their own.
If you’re still using ChatGPT to write Instagram captions or answer surface-level questions, you’re leaving serious growth on the table.
In this video, you’ll uncover 17 high-leverage AI strategies designed to scale your solo business, increase profitability, and eliminate guesswork.
You’ll discover how to:
- Audit your website and landing pages using Google AI’s Realtime Feedback — like having a 24/7 marketing analyst
- Analyze your last six months of email campaigns to uncover revenue leaks and performance goldmines
- Write higher-converting subject lines, sales pages and ads — based on what’s proven to work
- Reverse-engineer viral competitor content, pricing models and bonus stacks
- Perform deep market research without paying $200 per month for bloated SEO software
- Extract customer pain points from Amazon reviews and turn them into powerful marketing angles
- Automate onboarding, voiceovers and short-form content using tools
- Streamline your business using pre-built GPTs and personalized AI workflows to save hours each week
These are the same tools and tactics I’ve used to dramatically boost conversions, free up time and run a lean, high-impact business.
No tech skills required — just a smarter way to grow. This isn’t about saving time. It’s about gaining leverage. If you’re ready to turn AI into your unfair advantage, this video is your roadmap.
Save it for later — and let’s dive in.
The AI Success Kit is available to download for free, along with a chapter from my new book, The Wolf is at The Door.
If you’re still using ChatGPT to write Instagram captions or answer surface-level questions, you’re leaving serious growth on the table.
In this video, you’ll uncover 17 high-leverage AI strategies designed to scale your solo business, increase profitability, and eliminate guesswork.
You’ll discover how to:
The rest of this article is locked.
Join Entrepreneur+ today for access.

A blog which focuses on business, Networth, Technology, Entrepreneurship, Self Improvement, Celebrities, Top Lists, Travelling, Health, and lifestyle. A source that provides you with each and every top piece of information about the world. We cover various different topics.
Business
Why I’ll Never Manage Money for Anyone for Free Again

About a year ago, a relative asked me to help manage her money. She had been paying a ~1% asset management fee with Goldman Sachs Asset Management (GSAM), even though she wasn’t their typical high-net-worth client. The account had been set up through her ex, but since she wanted a clean break, she was ready to move her money and asked for my guidance.
We scheduled a call—just like I do with consulting clients—to go over her financial situation, goals, and concerns. From there, we created an investment strategy designed to preserve her lifestyle and reduce the risk of running out of money. As an artist, finance was not something she really understood or ever got into.
Since she was also looking for a new brokerage, I recommended Fidelity, where I’ve had my accounts for over 20 years. I’m familiar with their platform, and with her permission, I’d be able to view her portfolio and make trades on her behalf.
By transferring her assets out of GSAM, she eliminated the 1% management fee and I rebuilt her IRA portfolios using low-cost ETFs with a similar asset allocation—saving her thousands a year in fees while maintaining long-term growth potential.
However, after about a year, I don’t want to manage money for anyone for free again. It’s nothing personal. I just want to preserve more time and energy for my family.
Table of Contents
Why I’d Like To Stop Managing Money or Free
We agreed on an asset allocation, and I built it out for her. For the second half of 2024 and into early 2025, everything went smoothly. Her portfolio steadily climbed to all-time highs, and I didn’t hear from her once. No problem. I felt proud to grow her wealth, especially since she doesn’t earn much active income. Her portfolio will be her main financial support in the future.
But in late March and early April 2025, her portfolio took a hit due to the trade wars, and I got a sudden text asking what was going on. So we got on another call and I explained the situation and tried to calm her nerves. Then came the inevitable question: “What should we do now?”—a fair concern for anyone who has entrusted their money to someone else.
But now I started to feel the pressure. What if I made the wrong recommendation at the wrong time?
Note: If you have over $100,000 in investable assets, you can receive a free financial analysis from an Empower advisor by signing up here. An annual review is always worthwhile as your asset allocation can shift significantly over time, and your financial situation may evolve as well. We all have financial blindspots that are worth recognizing to build more future wealth.
To Some, Outperforming Is Not Enough
I reminded her of our game plan and emphasized the importance of staying the course. I also shared my outlook on why the markets were likely to rebound in the second half of the year—citing factors like trade agreements, deregulation, and potential tax cuts.
Given we had constructed a 60/40 portfolio, when the S&P 500 was down ~20% year-to-date on April 8, her portfolio was only down 8.8%. From my perspective, that was a win!
But from her perspective, I had still lost her money. And since she wasn’t a fan of the current administration, the situation felt even more frustrating to her.
It didn’t really matter that I highlighted her portfolio’s outperformance or the rationale behind a balanced allocation. She was disappointed—and that, in turn, chipped away at some of my emotional resilience.
It doesn’t feel good to help someone who is disappointed in your help.
Already Stressed With My Own Losses
At the time, I was already stressed about my own portfolio losses, which were approaching seven figures. I was buying the dip, watching values continue to fall, and doing my best to stay calm. But deep down, I felt like a fool for jumping in too early with the proceeds from my stable real estate sale.
Her stress added to mine, and I had to compartmentalize my own emotions to reassure her. It left me with less patience for my wife and kids, which was the biggest negative since I love them more than anything. And when I’m losing a lot of money, I admit I tend to have a shorter fuse.
During the bull market, I didn’t hear a word of acknowledgement. But as soon as things took a turn, I was met with concern and urgency. Again, totally understandable. However, I was cast in the role of an unpaid employee, bringing back the very feelings of underappreciation that pushed me to leave the traditional workforce.
If I’m expected to actively manage someone’s portfolio and provide emotional support and education during downturns, there needs to be clear compensation or boundaries. Otherwise, I’d rather preserve my energy for writing and taking care of the kiddos.
After being free from a day job since 2012, I probably have become overly sensitive to anything that reduces my sense of freedom and joy. As a result, I’m not cut out to be a money manager at this stage in my life.
The Problem With Double Fees
I was happy to help move my relative’s funds away from GSAM to reduce the double fees she was paying. She was being charged an asset management fee of about 1%, plus fund fees ranging from 0.5% to 1.6%—mostly on Goldman-managed funds.
Now, I’m not against hiring an asset manager if you genuinely don’t have the time, interest, or knowledge to manage your own money. Paying a professional to build a risk-appropriate portfolio is far better than sitting in cash and missing out on decades of compounding. A good manager can also serve as an emotional buffer—helping prevent panic selling during downturns and reckless speculation during bull markets.
But paying double fees—especially as your portfolio grows—adds up quickly. A $5,000 annual fee on a $500,000 portfolio is one thing. But paying $25,000 on a $2.5 million portfolio, plus another $12,500 to $40,000 in fund fees, starts to feel excessive.
She needed to move her money and I was glad to help her do it.
Only Reason To Pay Double Fees
The only real justification for such fees is if the manager offers access to exclusive private investments with meaningful upside—say, a hot AI company likely to IPO at a much higher valuation in a year or two. But in this case, there was no such access.
I reviewed the historical performance of these funds, which was often difficult to find and intentionally opaque. But by simply comparing her portfolio value from a decade ago to when I started managing it, the compounded returns were clearly underwhelming. The double fees weren’t just costly—they were a drag on long-term performance.
Personally, I’m not interested in paying another 0.5%+ to own a repackaged basket of public stocks that attempts to beat an index.
In Defense of Getting Paid to Manage Money
Most DIY investors, myself included, aim to minimize fees. But after managing a relative’s portfolio for a year, I now get why financial professionals charge what they do—the emotional labor is real.
Managing money is relatively easy when markets are rising. It’s during downturns that things get difficult. And when you’re managing money for a family member, the emotional stakes are even higher. You really don’t want to let them down.
Advisors aren’t just managing assets; they’re managing expectations, fears, and behaviors. For that reason alone, they deserve to be compensated.
That said, fees should be fair and transparent. A flat 1% management fee feels outdated. Something less—with a tiered structure that declines as assets grow—makes more sense.
The Three Main Benefits Of Hiring A Money Manager
The real value of hiring a money manager is peace of mind. Knowing someone is actively looking after your portfolio means you can focus on doing what you enjoy or excel at, without constantly worrying about market volatility or portfolio drift. Reducing the mental load is huge, especially for parents juggling work and childcare. During times of stress, it’s reassuring to know someone else is thinking about ways to protect your wealth.
The second big benefit is consistency. A good advisor helps you stay disciplined—investing regularly, staying diversified, and adjusting risk over time. Even as a committed DIY investor, I’ve had long stretches where I didn’t invest simply because life got in the way.
The third benefit is accountability. A trusted advisor can act as a financial coach, helping you follow through on your goals. It’s one thing to know what you should be doing—it’s another to actually do it. Regular check-ins and objective feedback can keep you on track, especially during major life transitions or periods of uncertainty.
A financial professional who helps with these three areas is well worth it. If you’re receiving proactive service and your portfolio is meeting expectations, great. But if not, it’s only rational to explore better options.
I’m Stuck Managing the Money—But Not My Emotions
I’m OK to help my relative create an investment plan. After all, it’s something I’ve done for others for over 15 years. I also love to save people money when there is a clear way to do so. But I also need to protect my time and mental well-being, which means learning to emotionally detach.
My long-term goal is to teach her how to manage her own money. The challenge is, she struggles with learning about finances. Ironically, this makes her the exact type of person who benefits most from having someone manage her money for her.
So while I’ll continue to oversee her portfolio, I’m adjusting both the investment strategy and my mindset to reduce stress. She’s on board with the new, slightly more conservative asset allocation, which falls within an appropriate range for her age and long-term financial goals.
Further, to help offset the emotional load of managing her portfolio for free, I remind myself she’s saving at least $20,000 a year thanks to me. That cushion gives both of us more resilience in down markets. So the next time a concerned message comes through, I’ll remind both of us just how much she’s saving.
Appreciation Goes A Long Way
If someone is managing your portfolio for free, don’t forget to show your appreciation. A simple thank-you note can go a long way.
And if you don’t have someone to manage your money for free, consider hiring a money manager at a reasonable price. The reduction in stress alone may be well worth the cost.
Readers, do any of you manage a friend or relative’s money for free? If so, how have you structured that arrangement—and how do you handle the stress when they’re anxious about market volatility, especially while your own portfolio is also taking a hit?
Free Financial Analysis Offer
If you have over $100,000 in investable assets—whether in savings, taxable accounts, 401(k)s, or IRAs—you can get a free financial check-up from an Empower financial professional by signing up here. It’s a no-obligation way to have a seasoned expert, who builds and analyzes portfolios for a living, review your finances.
A fresh set of eyes could uncover hidden fees, inefficient allocations, or opportunities to optimize—giving you greater clarity and confidence in your financial plan.
I’ve been using Empower’s free financial tools and speaking with their financial professionals since 2012. From 2013 to 2015, I also consulted part-time at their offices when they were still called Personal Capital. As both a longtime user and affiliate partner, I’m genuinely pleased with the value they’ve consistently delivered over the years.
The statement is provided to you by Financial Samurai (“Promoter”) who has entered into a written referral agreement with Empower Advisory Group, LLC (“EAG”). Click here to learn more.

A blog which focuses on business, Networth, Technology, Entrepreneurship, Self Improvement, Celebrities, Top Lists, Travelling, Health, and lifestyle. A source that provides you with each and every top piece of information about the world. We cover various different topics.
Business
Standard Chartered CEO: Wharton MBA Was a ‘Waste of Time’

Bill Winters, the CEO of 160-year-old bank Standard Chartered, says that the MBA he earned from the University of Pennsylvania Wharton School of Business was a “waste of time” — but the humanities undergraduate degree he received from Colgate University was more worth it.
In an interview that aired earlier this week, Bloomberg’s Francine Lacqua asked Winters, 63, what he would recommend for young people to study. Winters responded by saying that he studied international relations and history as an undergraduate, graduating in 1983. He recommended those fields, stating that majoring in those areas taught him “how to think.”
But his MBA from Wharton in 1988 was unnecessary, he said.
“I got an MBA later, but that was a waste of time,” Winters told Bloomberg. “I learned how to think at university. For the 40 years since I left university, those skills have been degraded, degraded, degraded.”
Related: Goldman Sachs CIO Says Coders Should Take Philosophy Classes — Here’s Why
Winters explained that critical thinking skills are “coming back” and becoming more important in the workforce now because AI is taking over tasks on the technical side.
“I really think in the age of AI that it’s critical that you know how to think and communicate,” Winters said.
He clarified that communication doesn’t mean to act like ChatGPT and churn out answers, but to know an audience and anticipate their needs with curiosity and empathy. Technical skills are being needed “less and less,” Winters said.
Bill Winters. Photographer: Jason Alden/Bloomberg via Getty Images
Winters started his career at JPMorgan in 1983, rising over nearly three decades to become the co-CEO of JPMorgan’s investment bank. He was considered a potential successor to JPMorgan CEO Jamie Dimon, but was ousted by Dimon in October 2009. He started his own fund management business, Renshaw Bay, in 2011 and joined Standard Chartered as CEO in 2015.
Related: Using ChatGPT? AI Could Damage Your Critical Thinking Skills, According to a Microsoft Study
Winters isn’t the only executive encouraging the study of the humanities. Goldman Sachs’ Chief Information Officer, Marco Argenti, wrote in a post in the Harvard Business Review last year that engineers should take philosophy classes in addition to standard engineering courses. That’s the advice he gave his college-age daughter who was thinking about what to study.
Meanwhile, big tech companies are rapidly adopting AI in their operations as the technology sweeps over technical skills. AI generates about 30% of new code at Google and Microsoft, and up to half of software development within the next year at Meta.
“Vibe coding,” or having AI code entire apps and projects based on prompts, is also on the rise. Even Google CEO Sundar Pichai stated earlier this month that he had used AI coding assistants to “vibe code” a webpage in his spare time.
Bill Winters, the CEO of 160-year-old bank Standard Chartered, says that the MBA he earned from the University of Pennsylvania Wharton School of Business was a “waste of time” — but the humanities undergraduate degree he received from Colgate University was more worth it.
In an interview that aired earlier this week, Bloomberg’s Francine Lacqua asked Winters, 63, what he would recommend for young people to study. Winters responded by saying that he studied international relations and history as an undergraduate, graduating in 1983. He recommended those fields, stating that majoring in those areas taught him “how to think.”
But his MBA from Wharton in 1988 was unnecessary, he said.
The rest of this article is locked.
Join Entrepreneur+ today for access.

A blog which focuses on business, Networth, Technology, Entrepreneurship, Self Improvement, Celebrities, Top Lists, Travelling, Health, and lifestyle. A source that provides you with each and every top piece of information about the world. We cover various different topics.
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