News
How Will Martian Gravity Affect Skeletal Muscle?
NASA and the China National Space Agency (CNSA) plan to send astronauts to Mars as early as the next decade. Naturally, this ambitious goal requires a great deal of planning, research, and the anticipation and preparation for all potential challenges in advance. Among them, astronaut health and safety are paramount. In addition to the hazards associated with the long transit times – radiation and the effects of long periods in microgravity – there’s the issue of Mars itself. Aside from exposure to elevated radiation levels, Martian gravity is about 38% of Earth’s.
This has the potential to lead to long-term health risks. An international team of researchers is currently studying how Martian gravity will affect a key aspect of human health: skeletal muscle. This muscle, which is the most abundant tissue in the human body (accounting for more than 40% of total body mass), is essential to movement and metabolic health. What’s more, this tissue is especially sensitive, and lower gravity could potentially result in the substantial loss of muscle strength, size, and performance. It is therefore important to determine how this muscle tissue will fare in the Martian environment.
The research team was composed of scientists from the Institute of Medicine at the University of Tsukuba, Tohoku Medical Megabank Organization, the Advanced Research Center for Innovations in Next-GEneration Medicine (INGEM), the Beth Israel Deaconess Medical Center, the Brigham and Women’s Hospital, the Japan Aerospace Exploration Agency’s (JAXA) Space Environment Utilization Center, and multiple universities. The results of their research appeared in the journal Science Advances
*Experiments aboard the International Space Station with mice showed that muscle atrophy can be mitigated and prevented in lower gravity. Credit: NASA/ESA–T. Pesquet*
For their experiment, the team studied how lower gravity affected skeletal muscle tissue in 24 mice sent to JAXA’s Kibo experimental module. These mice were then placed in a JAXA-developed centrifuge device called the Multiple Artificial-gravity Research System (MARS), where they were subjected to four different levels of gravity – microgravity, 0.33 g, 0.67 g, and 1 g – over a 28-day period. The mice were subjected to pre-flight testing before launch at NASA’s Kennedy Space Center, where they were returned for post-flight sampling.
These samples were then examined by scientists at the Metabolism and Muscle Biology Lab in the Department of Nutrition at the University of Rhode Island (URI). As Professor Marie Mortreux, who leads the MMBL, attested in a Rhoby Today news story:
While we can simulate spaceflight on Earth in humans, it’s extremely complicated and costly. We have centrifuges that can be used to temporarily expose humans to certain gravity levels, but it is not homogeneous nor constant. We used gravity levels that were equally separated, to have a better picture of the dose-response of each system to gravity. The test group that was exposed to 0.33g was extremely close to Martian gravity (0.38g). Our findings for that group can be translated into actions to enable Mars exploration.
Mortreux and her team analyzed the weight, strength, and movement of the mice once they were returned to NASA’s Kennedy Space Center. Their analysis showed that 0.33 g mitigated spaceflight-induced muscle atrophy, with full prevention at 0.67 g. They also measured the mice’s forelimb grip strength using Electrical impedance myography (EIM), which showed that 0.67 g was sufficient to maintain muscle performance.
*The research team at Kennedy Space Center confirming the protocol and timing prior to receiving animals for post-flight sampling. Credit: URI*
Their results collectively demonstrated that 0.67 g is a critical threshold for mitigating muscle atrophy caused by prolonged spaceflight. In addition, an analysis of the mice’s blood plasma identified 11 metabolites that showed gravity-dependent changes, suggesting they could serve as potential biomarkers to monitor physiological adaptations in astronauts. This work builds on previous research she performed with Professor Mary Bouxsein (a co-author on the study) at Harvard Medical School.
Whereas Dr. Bouxsein developed the ground-based mouse model of partial gravity in the early 2010s, Montreux developed the rat model of partial gravity at Harvard. As such, the two are well-acquainted with the impact that different gravity levels have on musculoskeletal tissues.
“Since this mission aimed to assess gravity as a continuum, we were perfectly positioned to see if our ground-based results had similar outcomes when reduced mechanical loading was applied in orbit,” said Montreux. “Working with an international team was challenging and exciting. I think my experience working in Italy, France, and the United States prepared me for those big-scale collaborations.”
One takeaway from this study is that future missions to Mars will need to be mindful of mitigating skeletal muscle loss during the long transit between Earth and Mars. For astronauts to maintain mobility, muscle strength, and carry out regular science operations. The same holds true for their physical health upon returning to Earth.
These findings suggest that rotating toruses would be a wise addition to any future spaceflight plans, a la NASA’s Non-Atmospheric Universal Transport Intended for Lengthy United States Exploration (NAUTILUS-X) and similar aspects.
Further Reading: Rhody Today, Science Advances
News
Riverside County Sheriff Chad Bianco seizes more than half a million ballots
Riverside County Sheriff Chad Bianco, who is a leading Republican candidate for governor, has seized more than 650,000 ballots from last November’s election and is investigating whether they were fraudulently counted.
“This investigation is simple: Physically count the ballots and compare that result with the total votes recorded,” Bianco said at a news conference Friday.
The unusual probe drew a sharp rebuke from California Atty. Gen. Rob Bonta, who said in a statement Friday that it is “unprecedented in both scope and scale” and appears “not to be based on facts or evidence.”
“There is no indication, anywhere in the United States, of widespread voter fraud,” Bonta said. “Counts, recounts, hand counts, audits, and court cases all support this.”
According to Bonta’s office, Bianco’s department on Feb. 26 seized about 1,000 boxes of ballot materials in Riverside County related to the November election for Proposition 50, which temporarily redrew the state’s congressional districts to favor Democrats in response to partisan redistricting in Republican states, including Texas.
The sheriff said his investigators are looking into allegations by a local citizens group that “did their own audit” and found that the county’s tally was falsely inflated by more than 45,000 votes — a claim that local election officials have refuted.
President Trump, who remains fixated on his 2020 election loss, continues to amplify election conspiracy theories and has repeatedly called for the federal government to “nationalize” state-run elections to counter what he says is widespread fraud.
Bonta and California Secretary of State Shirley Weber, both Democrats, have vowed to fight federal interference that could affect voting in California, including efforts to seize election records, as the FBI recently did in Georgia.
Bianco is an outspoken Trump supporter who said in an endorsement video in 2024 that, after 30 years of putting criminals in jail, he figured it was “time to put a felon in the White House — Trump 2024, baby” — referencing Trump’s conviction by a New York jury for falsifying business records.
Bianco’s investigation, which includes all the ballots cast in Riverside County in November, raises questions about how he would handle the election denialism movement if elected governor.
A poll released last week by UC Berkeley’s Institute of Governmental Studies and co-sponsored by The Times showed Bianco and conservative commentator Steve Hilton leading the crowded field of gubernatorial candidates by slim margins, in a left-leaning state.
Last fall, Prop. 50 passed in Riverside County with 56% of the vote — a margin of more than 82,000 ballots.
A citizens group called the Riverside Election Integrity Team has said it performed an audit finding that 45,896 more ballots were counted than were cast.
In a lengthy February presentation to the Riverside County Board of Supervisors, Registrar of Voters Art Tinoco disputed that figure, saying it was based on a misunderstanding of raw data that had not been fully processed.
The actual discrepancy, Tinoco said, was 103 votes, a variance of 0.016% that was far below what he said was the state’s preferred 2% margin of error for certifying results.
Bianco on Friday said that there “is no acceptable error, small or large, in our elections.”
The sheriff did not name the Riverside Election Integrity Team, but his description of the allegations brought to him by “a group of citizen volunteers” matched theirs.
Bianco said the investigation was “not a recount” for the Prop. 50 contest and was “just as much to prove the election is accurate as it is to show otherwise — we will not know until the count is complete.”
Bonta said his office has “attempted to work cooperatively” with the Sheriff’s Department to understand the basis for the probe. The sheriff, Bonta said, “has delayed, stonewalled, and otherwise refused to work with us in good faith” and failed to provide most of the requested documents.
“We’re concerned that there is not sufficient justification for seizing every ballot that was cast in this very largely populated county,” an official in Bonta’s office said in an interview Friday night.
In a March 4 letter to Bianco, the attorney general cited Bianco’s plan to use sheriff’s department staffers, “who are not trained and have no experience,” to count the ballots.
“Let me be clear: this is unacceptable,” Bonta wrote. “Your decision to seize ballots and begin counting them based on vague, unsubstantiated allegations about irregularities in the November special election results sets a dangerous precedent and will only sow distrust in our elections. You are also flagrantly violating my directives.”
At his news conference Friday, Bianco fired back by calling Bonta “an embarrassment to law enforcement.”
A Riverside County Superior Court judge, Bianco said, has ordered the appointment of a special master to oversee the ballot count.
In a statement Friday, Secretary of State Weber said “the Sheriff’s assertion that his deputies know how to count is admirable. The fact remains that he and his deputies are not elections officials and they do not have expertise in election administration.”
News
Trump’s Recklessness Will ‘Haunt Us for a Generation’
Three Opinion writers on Iran, the SAVE Act and the president’s folly.
News
Saturn-mass world discovered orbiting two low-mass stars
You just established a settlement on an Earth-like planetary body far from our solar system. You did your evening chores after eating dinner, and you want to go out for the evening view, which consists of two setting stars, reminiscent of the infamous scene in Star Wars. However, there’s one major difference: a large planetary body is in the sky. As you were aware before arriving, you’re on an exomoon orbiting a Saturn-sized exoplanet, both of which orbits two stars.
While this incredible experience might be centuries away, this hasn’t stopped a large international team of researchers from announcing the discovery of a Saturn-sized exoplanet orbiting two M-dwarf stars, which are smaller and cooler than our Sun. The findings from this incredible discovery were recently published in the Publications of the Astronomical Society of the Pacific and were made using a lesser-known exoplanet discovery method known as gravitational microlensing, or microlensing for short.
The researchers are designating the discovery as the microlensing event KMT-2016BLG-1337L, is located approximately 7,000 parsecs (22,800 light-years) from Earth. The researchers used a series of light curve models to ascertain the masses of the exoplanet, stars, and orbital distances for both.
While the first model estimated the exoplanet is estimated to be 0.3 Jupiter masses and an estimated distance from its host star of 4 astronomical units (AU), the second model estimates the exoplanet is approximately 7 Jupiter masses with an estimated distance of 1.5 AU. For context, the planet Saturn is approximately 0.3 Jupiter masses. Despite this disagreement of the exoplanet mass and orbital distance, both models were consistent in their estimates of the two M-dwarf stars that comprise the binary star system, estimated to be 0.54 and 0.40 masses of our Sun and separated by approximately 3.5 AU.
The study notes, “The event KMT-2016-BLG-1337L underscores the capability of microlensing to reveal planets in dynamically complex stellar environments, including systems that are inaccessible to conventional detection techniques. This expands the census of planets in multiple-star systems and contributes to a more comprehensive understanding of planet formation in such environments.”
As noted, microlensing is a lesser-known exoplanet discovery method, being responsible for confirming just over 250 exoplanets of the more than 6,100 confirmed exoplanets. As its official name implies, microlensing uses the gravity from one star as a lens to magnify the light from a background star when a planet passes in between both stars. Since a star’s gravity is so massive, it warps (or bends) the observed space around it, while also enabling light from behind it through this warped region and be observed from our point of view. This differs from the transit method, which is the most common exoplanet discovery method, as it detects a dip in starlight as a planet passes in front of it. In contrast, microlensing requires two stars for the method to be successful and for an exoplanet to be detected passing between both stars.
While this discovery is notable, KMT-2016BLG-1337L is not the only Saturn-mass exoplanet discovered using the microlensing method, as the researchers note that OGLE-2007-BLG-349L was the first confirmed exoplanet in a binary system, also being a Saturn-sized planet whose findings were published in The Astronomical Journal in 2016. The major difference between the two discoveries is KMT-2016BLG-1337L orbits one of the two stars while OGLE-2007-BLG-349L orbits both stars at once. KMT-2016BLG-1337L orbiting only one star also demonstrates how planets can survive form, evolve, and survive orbiting a single star without the second star influencing its formation and survival.
How many more Saturn-sized exoplanets will be discovered using the microlensing method in the coming years and decades? Only time will tell, and this is why we science!
As always, keep doing science & keep looking up!
-
Trending3 weeks agoРоссийские СМИ сообщили о самоубийстве Умара Джабраилова
-
Trending3 weeks agoWolverhampton Wanderers vs Liverpool: Premier League preview, team news, stats & head-to-head
-
News3 weeks agoYoung mother found dead after being swept away on Bridge to Nowhere trail
-
Trending2 weeks agoThe day JFK Jr tickled Daryl Hannah topless on a Manhattan rooftop… truth about ‘cocaine obsession’… and REAL reason they split
-
Entertainment3 weeks agoParis Hilton poses nude in bathtub photos showing off skincare brand Parivie Beauty
-
Entertainment3 weeks agoJack Schlossberg eviscerates Ryan Murphy for his Kennedy-based series ‘Love Story’: ‘Grotesque’
-
News3 weeks ago
Trump Says More U.S. Casualties Are ‘Likely’ in War With Iran, and Oil Prices Jump After Attack
-
News2 weeks agoIllinois and UChicago Physicists Develop a New Method for Measuring Cosmic Expansion
