Protein helps old blood age the brain of young mice

Protein helps old blood age the brain of young mice

Old blood can prematurely age the brains of young mice, and scientists may now be closer to understanding how. A protein positioned in the cells that form a barrier between the brain and blood will be partly to blame, experiments on mice suggest.

If something comparable happens in humans, scientists say, methods for countering the protein might also keep the promise for treating age-related brain decline.

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The preliminary research, published online January 3 at bioRxiv.org, focused on a form of the protein called VCAM1, which interacts with immune cells in response to inflammation. As mice and humans age, levels of that protein circulating in the blood rise, Alzheimer researcher Tony Wyss-Coray at Stanford University and associates determined.

Protein helps old blood age the brain of young mice

After injecting young mice in the back of an eye fixed with plasma from old mice, the team determined that VCAM1 levels also rose in certain parts of the blood-brain barrier, a mesh of tightly woven cells that help to protect the mind from harmful factors inside the blood.

The young mice confirmed signs and symptoms of brain deterioration as well, consisting of inflammation and reduced birthrates of new nerve cells. Plasma from young mice had no such effects.

Interfering with VCAM1 may also assist save you the premature ageing of brains. Plasma from old mice didn’t have a strong effect when injected into younger mice genetically engineered to lack VCAM1 in certain blood-brain barrier cells.

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Nor did it have an effect on mice treated with antibodies that blocked the activity of VCAM1. Those antibodies also seemed to assist the brains of older mice that had aged evidently, the group discovered.

The outcomes suggest that anti-ageing treatments concentrated on particular elements of the blood-brain barrier may hold promise.

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Technology

Facebook Live Group Video Chat Feature

Here are Facebook Live Group Video Chat Feature

Facebook is now going to duplicate another application, after copying the biggest feature of snap chat to make Instagram stories, House Party, a group video chat application that rose from the ashes of a meerkat. The Bonfire application was recently shown for employees.

A Facebook spokeswoman said, “We don’t have anything to share at this time.”

Facebook Live Group Video Chat Feature

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The Houseparty is an application which notifies a user’s friends when they open the application, inviting them to hang out virtually on their mobile phones.

The application is very popular among the teenagers and by Nov 2016 it had 1.2 million users sit for 20 million minutes a day using this application.

Facebook become worried that the new app is growing very quickly among the teenagers that’s why the company first get the snap chat features and now moving to clone its most distinctive features. And while the firm seems to have struck gold with Instagram stories, its refined take on ephemeral public posts of snap chat, such type of products in the Facebook main application and in Facebook Messenger has increased a little enjoyment among the Facebook users.

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Bonfire is not only a single video application Facebook is pursuing. Employees have also seen an application which is called as ‘Talk’. The app is designed to encourage the teenagers to connect and communicate with their relatives and grandparents using the video chat.

https://youtu.be/ADnmMMbSuOA

Here are advantages of Facebook Live Group Video Chat Feature:

By the invention of internet communications become easy for everyone. When you want to see a person then you easily contact by just one call, it may be a voice or a video call.
Facebook introduce a live video chat feature. Which is very good friends or family easily talk with each other in such a way that they talk with each other as face to face.

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Conclusion:

By the invention of internet communications become easy for everyone. When you want to see a person then you easily contact by just one call, it may be a voice or a video call.
Facebook introduce a live video chat feature. Which is very good for friends or family easily talk with each other in such a way that they talk with each other as face to face.

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Travel

6 Historical Castles for Sale in Europe

There interesting facts about 6 Historical Castles for Sale in Europe.

Fancy a chunk more area? Why not buy such a historical castles, ranging from simply over $1 million to almost $12 million.

Table of Contents

Here are 6 Historical Castles for Sale in Europe:

Carbisdale Castle, Highlands, Scotland
Hellifield Peel Castle, Yorkshire, England
Shonnard Terrace, Yonkers, New York
Glin Castle, Co. Limerick, Ireland
Chateau de Castille, Provence, France
Inniscorrig Castle, County Dublin, Ireland

1. Carbisdale Castle, Highlands, Scotland

6 Historical Castles for Sale in Europe

While this is the cheapest citadel on the listing, at just over $1 million, there’s a slight catch: the new owner of the 40-bedroom carbies Dale Castle, In the Scottish Highlands, will have to foot the invoice for renovations and some a good deal needed upkeep—and might also need to lease an exorcist. This is due to the fact the fort has a resident ghost, called Betty, who are said to roam the halls wearing white.

Cost: $1.2 Million

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2. Hellifield Peel Castle, Yorkshire, England

6 Historical Castles for Sale in Europe

This castle, which dates returned to the 1300s, laid in ruins for 50 years till the Shaw family bought it in 2004 and brought it again to existence. The recovery became countrywide information inside the UK. While it becomes featured on “grand designs,” a famous domestic maintenance television program. Some 6 million visitors watched because the fort turned into reconstructed as a family domestic with grand reception rooms and bedrooms, modern-day services and sweeping views over the tranquil North Yorkshire geographical region.

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Cost: $2.2 Million

3. Shonnard Terrace, Yonkers, New York

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Built in the 1880s, this opulent completely renovated 20-room fort has become quite the celebrity seeing that its proprietor began renting it out for movies, TV programs, and fashion shoots. It has appeared in the Julia Roberts movie “Mona Lisa Smile,” Martin Scorsese’s HBO drama “Boardwalk Empire” and the CW collection “gossip woman.” It also starred in the music video for beyoncé’s track “Irreplaceable.”

Cost: $3.95 Million

4. Glin Castle, Co. Limerick, Ireland

This fort, which sits on 380 acres overlooking the Shannon Estuary, has belonged to the same family for 700 years. now, the 18-bedroom fort in County Limerick is up on the market for the first time. This represents a rare possibility, the listing agent informed mansion global, as Irish castles do no longer come onto the market very frequently, in particular now not at this stage of nice.

Cost: $7.2 Million

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5. Chateau de Castille, Provence, France

6 Historical Castles for Sale in Europe Chateau de Castille, Provence, France

Situated in the province within the South of France, this château dates to the thirteenth century, but possibly the maximum exciting element to happen in the 20th century. While British art historian and collector Douglas Cooper purchased the castle in 1950, Pablo Picasso has become a common tourist and left his mark in the form of 5 frescoes that have been sandblasted into the partitions. Those had been labeled, collectively with different elements of the castle, as “ancient monuments” by using the French authorities.

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Cost: $9.66 Million

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6. Inniscorrig Castle, County Dublin, Ireland

Perched on top of a cliff 10 miles away from the Dublin, this castellated mansion has outstanding sea views, which stretch from Dun Laoghaire over the Bay to Howth peninsula, taking in the rocky seashore and Dalkey Island and the Muglins. What’s extra, it additionally has its own personal working harbor, considered one of handiest two in private palms in Dublin.

Cost: $11.6 Million

Conclusion:

In this article you know about the most beautiful castle for sale in Europe. You also know about the structure of these beautiful castle and also cost. These castle are located in beautiful places of Europe. Like some of these beautiful castles situated near sea side which enhance its beauty.

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Technology

Watch Youtube Videos on Whatsapp

a green square button with a white q on it

Here is discussion about Watch YouTube Videos on WhatsApp.

All of us know how traumatic it’s miles while you get hold of a YouTube link in WhatsApp and upon clicking it the app opens the YouTube app to play the video.

However, this toggling between the apps is set to change with the trendy WhatsApp feature. WhatsApp’s new update consists of a hidden feature that let you view youtube videos immediately within the app.

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Though YouTube video play feature is covered within the latest WhatsApp update launched on the app store, it’s miles nevertheless hidden and may be officially activated once it’s ready.

The Picture in Picture Mode:

The new feature implemented in WhatsApp makes use of the picture in picture idea to allow users view youtube videos inside your WhatsApp chats.

You can pinch at the picture in picture mode in order to amplify it, or you can open the video in a new WhatsApp phase to view it in full-screen mode.

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In addition, you can also momentarily hide the picture in picture mode without stopping the video to view your messages.

This feature is of route nevertheless being kept below the wraps because it does not glitch free. Presently, it’s not possible yet to keep active the video in case you change the chat as the picture in picture mode will disappear.

However each time Whatsapp officially launches this feature, it surely will make things less complicated.

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https://youtu.be/S7AZ5bkts1M

Facebook Live Group Video Chat Feature

There’s no news yet about its availability to android and windows phone users. It’s miles pertinent to mention here that the function will handiest be like minded for the iPhone collection starting from iPhone 6 and beyond as previous versions can’t support the function in terms of screen size.

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Advantages of Watch YouTube Videos on WhatsApp:

Now WhatsApp introduce it’s amazing feature which allow you to watch video while using WhatsApp. When you send YouTube video link to some then other person click on this link he or she watch video without using YouTube. It’s is very easy to see video while using WhatsApp.

Conclusion:

Before this feature there are many difficulties when user wants to watch a video while user use WhatsApp. Then WhatsApp introduce it’s new feature which allow users to not only watch videos but also comment on videos without any interruption in using WhatsApp.